In this informationscape, one of the most prominent identities of the gene is as information, code, program, blueprint, recipe, and ‘book of life’. These metaphors dominate popular understanding of genetics and molecular biology. A good deal of scepticism has been expressed about these ideas by biologists and philosophers of biology. The idea of genetic information has been dismissed as merely metaphorical, or, slightly more positively, as referring to a loose collection of analogical models which make heuristic use of several different points of resemblance between molecular processes and human communication systems. Invoking the physics and chemistry underlying the substrate as a promising area in breaking the so-called perennial mystery argues for the importance of Francis Crick’s 1958 definition, which relates directly to the actual genetic code: “information means here the precise determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein.” Surprisingly, this definition can be generalised to apply to non-genetic factors in development. Doing so makes it possible to state clearly why the origin of nucleic acid-based heredity was an evolutionary ‘key innovation’ which made possible the evolution of complex life, while maintaining a balanced view of the role of genetic and other causes in the developmental biology of modern organisms. Quoting Deleuze in the appendix to his book on Foucault, where the very notion of overman, superman or expansiveness is lying outside the constraint of the usual anthropological forms of the human, and this expansiveness could be looked into by two means viz, the potential foldings proper to the chains of the genetic code, and the potential of silicon in the third generation machines. It is the latter versus the former, which is crucial here for consciousness to break free of human-centric logic.